Researchers found that children in care have less grey and white matter - the two components of the central nervous system - than those brought up in a typical home environment.
Children in foster families have normal levels of white matter, which relays messages in the brain, but less of the grey matter which contains nerve cells and controls muscles, memory, emotions and speech.
Scientists believe the findings could explain why children who spend time in care are statistically more likely to develop issues such as attention deficit hyperactivity disorder and mental health problems.
People who have been in care also have, on average, lower IQ and language skills than those who grew up in loving homes.
The differences in levels of grey and white matter is most likely to be due to varying levels of stimulation required for normal brain development, researchers said.
Many children in care have been exposed to deprivation and neglect, which could be linked to their lower levels of grey and white matter.
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